Taken from : Trubus Magazine 482 - January 2010/XLI
Who would not shudder to hear the word AIDS, decreased immune system due to human immunodeficiency virus HIV infection which triggered the emergence of various diseases? According to data from the World Health Organization (WHO), about 2 million people worldwide died from AIDS during 2008. That number may go down if people living with AIDS know Propolis.
Propolis is not yet clinically proven able to cope with HIV. However, based on in vitro laboratory research done by researchers from the University of Minnesota, Minneapolis, United States, Propolis has the potential to boost immunity of people living with HIV / AIDS. The research team suspected antiviral substances contained in propolis inhibit viral entry into CD4 + lymphocytes.
Propolis dose of 66.6 ug / ml in cell culture of CD4 + T cells in the immune system that have CD4 receptors capable of inhibiting expression of a maximum of 85% of the HIV virus. Prevalent in people with HIV / AIDS, the deadly virus to infect cells that have CD4 receptor. Hence, the number of CD4 cells in patients were HIV / AIDS fall far below the normal figure. In healthy people number around 500 - 1.500/mm3 blood.
Serious Illness
Based on the outside and domestic research, Propolis is proven effective against several serious diseases. Dr.dr. Eko Budi Koendhori MKes from the Department of Microbiology, Faculty of Medicine Airlangga University for example, prove the bee glue that helps reduce damage to lung tissue in mice infected with Mycobacterium tuberculosis (TB).
Of the 100 mice infected by M. tuberculosis, mice given a combination of antituberculosis drugs Isoniasid 25 mg / kg body weight and propolis showed elevated levels of interferon γ. Interferon γ plays mikrofag activate cells that kill TB bacteria. Mice that were given only isolation increased lung damage from week 5 to the 12. While the condition of lungs of mice given the isolation and propolis dose of 800 mg at week-12 the same as in week 5.
Propolis served to increase the patient's immune so that tissue damage can be depressed. Standard drug works directly attack the TB bacteria. Propolis lethal combination of drugs and the TB bacteria while reducing lung damage due to bacterial attack. " Propolis is great for improving immune. Other than that i guess has the ability anticancer " said Eko.
CANCER
Alleged Eko did not miss. Based on research conducted at the Integrated Testing and Research Laboratory (LPPT) Gadjah Mada University, who studied propolis products can inhibit cancer cells Hela (cervical cancer cells), Siha (uterine cancer) and T47D and MCF7 (breast cancer cells) with IC50 values range 20-41 ug / ml. That is, propolis dose of 20-41 ug / ml can inhibit the activity of 50% of cancer cells in culture.
That's in line with the research of dr. Woro Pratiwi Kes, SpPD, from the Faculty of Medicine, University of Gadjah Mada. Propolis is given for a month to have anticancer effects in living organisms. It was shown by the lower number of nodules or bumps and decreased tumor proliferation activity, doubling the breast gland tumor cells in mice. But the effect is still lower than in the mice given standard cancer drugs, doxorubicin. "So it is necessary to study the use of Propolis with anti-cancer drugs standardized to provide the optimal therapeutic effect and minimal side effects," said Woro.
Polyphenols and flavonoids, which contained some compounds likely play a role in propolis inhibit cancer cell proliferation. According to Drs. Edy Melyanto from the Faculty of Pharmacy Gadjah Mada University, flavonoids usually have a distinctive structure that is able to inhibit protein kinases that are used for cell proliferation. If the protein kinase is inhibited, cell physiology processes so that the cells do also inhibited apoptosis, aka create a program to commit suicide.
Flavonoid compounds and polyphenols that are in the Propolis also has antioxidant effects and antitrombositopenia, "said Prof. Dr. Mustafa MKes Apt from Section of Pharmacology & Toxicology Faculty of Medicine, University of Gadjah Mada. Research indicated that the compound tested Propolis can prevent platelet decline in mice infected with Plasmodium berghel, one of the parasite that causes malaria in mammals other than humans. Dose of 5 ml / kg body weight was also able to increase the number of erythrocytes up to 37% after 8 days of administration.
SAFE
Other efficacy of propolis that have been proven through research that the antimicrobial effects. Tests conducted in 2007 showed Eko Propolis is capable of killing 26 isolates of Staphylococcus aureus bacteria that cause infections of the skin and respiratory tract and digestive tract penginfeksi Escherichio coli. Propolis dose 10% and 20% are able to kill the entire sample of both types of bacteria.
Similar research by Dr. Jessie Pamudji at the School of Pharmacy, Bandung Institute of Technology proved the antibacterial effect of propolis against S. aureus and Propionibacterium acnes, pimples starter. "That's because Propolis contains compounds that are antimicrobial which pinocembrin flavone, flavonol galangin and kafeat acid," says Jessie.
Above all, research proves safe propolis although consumed in the long term. According to Dra. Mulyati Sarto, MSI from the University of Gadjah Mada LPPT, very low toxicity of propolis. "Pressed Propolis given every day for 1 month with normal dose, the function of organs and conditions remain good, no problem," he said.
The normal dosage is equivalent to 1 tablespoon of propolis was dissolved in 50 ml of water for human consumption. Propolis is a new cause of death half the number of test animals at doses above 10,000 mg / kg body weight. If converted to a human weighing 60 kg, the dose was equivalent to the consumption of 0.6 kg of propolis each day. This means that the efficacy and safety of propolis superbly evident. (Tri Susanti / covering: Faiz Yajri, Nesia Artdiyasa & Rosy Nur Apriyanti)
Propolis dose of 66.6 ug / ml in cell culture of CD4 + T cells in the immune system that have CD4 receptors capable of inhibiting expression of a maximum of 85% of the HIV virus. Prevalent in people with HIV / AIDS, the deadly virus to infect cells that have CD4 receptor. Hence, the number of CD4 cells in patients were HIV / AIDS fall far below the normal figure. In healthy people number around 500 - 1.500/mm3 blood.
Serious Illness
Based on the outside and domestic research, Propolis is proven effective against several serious diseases. Dr.dr. Eko Budi Koendhori MKes from the Department of Microbiology, Faculty of Medicine Airlangga University for example, prove the bee glue that helps reduce damage to lung tissue in mice infected with Mycobacterium tuberculosis (TB).
Of the 100 mice infected by M. tuberculosis, mice given a combination of antituberculosis drugs Isoniasid 25 mg / kg body weight and propolis showed elevated levels of interferon γ. Interferon γ plays mikrofag activate cells that kill TB bacteria. Mice that were given only isolation increased lung damage from week 5 to the 12. While the condition of lungs of mice given the isolation and propolis dose of 800 mg at week-12 the same as in week 5.
Propolis served to increase the patient's immune so that tissue damage can be depressed. Standard drug works directly attack the TB bacteria. Propolis lethal combination of drugs and the TB bacteria while reducing lung damage due to bacterial attack. " Propolis is great for improving immune. Other than that i guess has the ability anticancer " said Eko.
CANCER
Alleged Eko did not miss. Based on research conducted at the Integrated Testing and Research Laboratory (LPPT) Gadjah Mada University, who studied propolis products can inhibit cancer cells Hela (cervical cancer cells), Siha (uterine cancer) and T47D and MCF7 (breast cancer cells) with IC50 values range 20-41 ug / ml. That is, propolis dose of 20-41 ug / ml can inhibit the activity of 50% of cancer cells in culture.
That's in line with the research of dr. Woro Pratiwi Kes, SpPD, from the Faculty of Medicine, University of Gadjah Mada. Propolis is given for a month to have anticancer effects in living organisms. It was shown by the lower number of nodules or bumps and decreased tumor proliferation activity, doubling the breast gland tumor cells in mice. But the effect is still lower than in the mice given standard cancer drugs, doxorubicin. "So it is necessary to study the use of Propolis with anti-cancer drugs standardized to provide the optimal therapeutic effect and minimal side effects," said Woro.
Polyphenols and flavonoids, which contained some compounds likely play a role in propolis inhibit cancer cell proliferation. According to Drs. Edy Melyanto from the Faculty of Pharmacy Gadjah Mada University, flavonoids usually have a distinctive structure that is able to inhibit protein kinases that are used for cell proliferation. If the protein kinase is inhibited, cell physiology processes so that the cells do also inhibited apoptosis, aka create a program to commit suicide.
Flavonoid compounds and polyphenols that are in the Propolis also has antioxidant effects and antitrombositopenia, "said Prof. Dr. Mustafa MKes Apt from Section of Pharmacology & Toxicology Faculty of Medicine, University of Gadjah Mada. Research indicated that the compound tested Propolis can prevent platelet decline in mice infected with Plasmodium berghel, one of the parasite that causes malaria in mammals other than humans. Dose of 5 ml / kg body weight was also able to increase the number of erythrocytes up to 37% after 8 days of administration.
SAFE
Other efficacy of propolis that have been proven through research that the antimicrobial effects. Tests conducted in 2007 showed Eko Propolis is capable of killing 26 isolates of Staphylococcus aureus bacteria that cause infections of the skin and respiratory tract and digestive tract penginfeksi Escherichio coli. Propolis dose 10% and 20% are able to kill the entire sample of both types of bacteria.
Similar research by Dr. Jessie Pamudji at the School of Pharmacy, Bandung Institute of Technology proved the antibacterial effect of propolis against S. aureus and Propionibacterium acnes, pimples starter. "That's because Propolis contains compounds that are antimicrobial which pinocembrin flavone, flavonol galangin and kafeat acid," says Jessie.
Above all, research proves safe propolis although consumed in the long term. According to Dra. Mulyati Sarto, MSI from the University of Gadjah Mada LPPT, very low toxicity of propolis. "Pressed Propolis given every day for 1 month with normal dose, the function of organs and conditions remain good, no problem," he said.
The normal dosage is equivalent to 1 tablespoon of propolis was dissolved in 50 ml of water for human consumption. Propolis is a new cause of death half the number of test animals at doses above 10,000 mg / kg body weight. If converted to a human weighing 60 kg, the dose was equivalent to the consumption of 0.6 kg of propolis each day. This means that the efficacy and safety of propolis superbly evident. (Tri Susanti / covering: Faiz Yajri, Nesia Artdiyasa & Rosy Nur Apriyanti)
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